556 papers
This study utilizes genetic labeling and 3D imaging to demonstrate that lymphatic vessels in bone are strictly confined to periosteal and periarticular soft tissues, while being completely absent from the bone marrow.
This study uses a computational model to demonstrate that immune cells utilize autoattractants to coordinate collective migration, revealing that an optimal balance between signal production and removal creates a critical boundary where efficient chemotaxis is maximized just before the system transitions into inefficient aggregation.
Periodic red light exposure mitigates aging in mice by downregulating SIRT4 in keratinocytes, which activates fatty acid metabolism and the TCA cycle to increase acetyl-CoA and H3K9ac levels, thereby reshaping senescence-related gene expression through synergistic metabolic and epigenetic regulation.
This study systematically characterizes the expression and functional roles of RhoGAPs in Drosophila border cells, demonstrating that diverse RhoGAPs are essential for sculpting Rho GTPase activity to precisely control cell morphology and migration in vivo.
This study demonstrates that the reticulon homology domain of Pex30 generates local membrane curvature at ER subdomains, a mechanism essential for the biogenesis and proper morphology of lipid droplets.
By employing cryo-electron tomography to visualize the leading edge of human fibroblasts, this study reveals the diverse in situ structural architecture and dynamic interplay of focal adhesions with actin, vimentin, and microtubules, thereby establishing a new framework for understanding cytoskeletal integration and force transmission during cell migration.
Using a novel HJ-binding peptide approach (HJSeq), this study reveals that meiotic Holliday junctions undergo sustained, transcription-linked directional branch migration during pachytene, actively remodeling their genomic landscape away from double-strand break sites toward convergent transcription sites to ensure regulated crossover formation and faithful chromosome segregation.
This study demonstrates that Plekha7 is essential for maintaining retinal organization and preventing photoreceptor loss by regulating cadherin trafficking at apical junctions and influencing centrosome and cilia dynamics, largely independent of p120 catenin.
This study establishes a quantitative framework demonstrating that nanoplastics at physiologically relevant levels persist in vivo and broadly impair cell proliferation and motility across diverse cell types through novel ion and water transport pathways, with effects varying significantly by nanoplastic polymer type and extracellular environment.
This study reveals that multicellular handedness is determined not by single-cell chirality alone, but by the balance of chiral force transmission through cell-cell versus cell-substrate adhesions, a process regulated by microtubule-mediated recruitment of ACF7 to stabilize intercellular mechanical coupling.
This study demonstrates that modulating RhoA signaling can restore nucleus pulposus cell phenotype and matrix gene expression in both 2D and 3D cultures, though the optimal direction of modulation (inhibition vs. activation) depends on the specific microenvironmental context.
By integrating cryo-electron tomography, cross-linking mass spectrometry, and expansion microscopy, this study provides the first comprehensive in situ molecular and structural map of the mammalian multiciliated cell ciliary base, revealing detailed microtubule architectures, novel protein localizations, and the spatial organization of the surrounding cytoskeletal environment.
This study utilizes a pooled CRISPR-Cas9 screen in enucleated human red blood cells to identify CLIC3 and VAMP8 as critical regulators of terminal erythroid differentiation, which function through distinct mechanisms involving cell cycle coordination and actin-mediated nuclear polarization, respectively.
This review and feasibility study evaluates the potential of ocular mitochondrial transplantation for treating blinding diseases, demonstrating that while intravitreal, subretinal, and suprachoroidal delivery routes successfully target distinct retinal compartments, further research is required to optimize dosing, confirm intracellular uptake, and ensure safety.
This study utilizes longitudinal single-cell RNA sequencing to map the cellular and molecular dynamics of spontaneous lung fibrosis resolution, identifying the clearance of pro-fibrotic macrophages and the enrichment of anti-fibrotic signaling pathways across multiple cell types as key mechanisms for tissue repair.
This study demonstrates that while both Wnt-activating and Wnt-inhibiting conditions successfully generate gallbladder organoids, Wnt activation favors long-term propagation and increased gemcitabine sensitivity, whereas Wnt inhibition better preserves dysplastic features, revealing a critical trade-off between culture stability and histological fidelity for disease modeling.
The authors withdrew this manuscript because their original claim that the sorting nexin requirement for Vps68 recycling is context-dependent was incorrect, as overexpression artifacts and misattributed gene functions obscured the true retromer-dependent nature of the process, which has since been corrected in a new publication.
This study characterizes gestational changes in decidual natural killer (dNK) cell heterogeneity and function, demonstrating that induced pluripotent stem cells can be differentiated into functional, early-gestation-like dNK2 subtypes via TGF{beta} treatment, thereby establishing a novel platform for modeling reproductive diseases and developing cell-based therapeutics.
This study establishes the first bovine and ovine liver organoid models derived from primary tissue, revealing species-specific differences in immune and metabolic gene expression while validating their utility for studying liver function, drug metabolism, and toxicity in ruminants.
This study demonstrates that calcium signaling is essential for maintaining mouse embryonic stem cell pluripotency and cell cycle progression by regulating the post-translational stability of Oct4 and Nanog, as well as modulating post-transcriptional processes including mRNA decay and splicing.